Paper in Journal of Affective Disorders
  • McKinnon, A., Hickie, I., Scott, J., Duffy, S., Norrie, L., Terpening, Z., Grunstein, R., Lagopoulos, J., Batchelor, J., Lewis, S., Shine, J., Naismith, S. (2018). Current sleep disturbance in older people with a lifetime history of depression is associated with increased connectivity in the Default Mode Network. Journal of Affective Disorders, 229, 85-94.
    ABSTRACT


    • Investigated associations between depression history and sleep disturbance in older adults via rsfMRI in the DMN.

    • No prior studies have investigated the sleep, depression and the DMN to identify changes specific to sleep quality.

    • Aids elucidation of sleep and depression pathophysiology in ageing by demonstrating associated neurobiological changes.

    • Those with depression history and sleep disturbances have increased prefrontal-temporal functional connectivity.

    • The co-occurrence of depression and sleep disturbance appears to signal greater pathophysiological change in older adults.