Publications Archive

2008

Staples LG, McGregor IS, Apfelbach R, Hunt, GE. (2008) Cat odor, but not trimethylthiazoline (fox odor), activates accessory olfactory and defense-related brain regions in rats. Neuroscience 151, 937-947. PubMed

McGregor, IS, Callaghan, PD, Hunt, GE. (2008) From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use? British Journal of Pharmacology 154, 358-368. PubMed

Rutten K, Reneerkens OA, Hamers H, Sik A, McGregor IS, Prickaerts, J, Blokland, A. (2008) Automated scoring of novel object recognition in rats. Journal of Neuroscience Methods 171, 72-77. PubMed

Iwazaki T, McGregor IS, Matsumoto I. (2008) Protein expression profile in the amygdala of rats with methamphetamine-induced behavioral sensitization. Neuroscience Letters 435, 113-119. PubMed

Thompson MR, Callaghan PD, Hunt GE, McGregor IS. (2008) Reduced sensitivity to MDMA-induced facilitation of social behaviour in MDMA pre-exposed rats. Progress in Neuropsychopharmacology and Biological Psychiatry 32, 1013-1021. PubMed

Cornish JL, Clemens KJ., Thompson MR, Callaghan PD, Dawson B, McGregor IS. (2008) High ambient temperature increases intravenous methamphetamine self-administration on fixed and progressive ratio schedules in rats. Journal of Psychopharmacology22, 100-110. PubMed

Quinn HR, Matsumoto I, Callaghan PD., Long LE. Arnold, JC, Gunasekaran N., Thompson MR, Dawson B, Mallet PE, Kashem MA, Matsuda-Matsumoto H, Iwazaki T, McGregor IS. (2008) Adolescent rats find repeated Delta(9)-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure.Neuropsychopharmacology 33, 1113-1126. PubMed

Staples LG, Hunt GE, van Nieuwenhuijzen PS, McGregor IS. (2008) Rats discriminate individual cats by their odor: possible involvement of the accessory olfactory system. Neuroscience & Biobehavioral Reviews 32, 1209-1217. PubMed

2007

Boucher, A. A., Hunt, G. E., Karl, T., Micheau, J., McGregor, I. S., Arnold, J. C. (2007). Heterozygous neuregulin 1 mice display greater baseline and Delta(9)-tetrahydrocannabinol-induced c-Fos expression. Neuroscience, 149(4), 861-870. PubMed

McGregor, I. S., & Arnold, J. C. (2007). Cannabis reward: biased towards the fairer sex? Br J Pharmacol, 152(5), 562-564. PubMed

Hargreaves, G. A., & McGregor, I. S. (2007). Topiramate moderately reduces the motivation to consume alcohol and has a marked antidepressant effect in rats. Alcohol Clin Exp Res, 31(11), 1900-1907. PubMed

Hargreaves, G. A., Hunt, G. E., Cornish, J. L., & McGregor, I. S. (2007). High ambient temperature increases 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)-induced Fos expression in a region-specific manner. Neuroscience, 145(2), 764-774. PubMed

Iwazaki, T., McGregor, I. S., & Matsumoto, I. (2007). Protein expression profile in the striatum of rats with methamphetamine-induced behavioral sensitization. Proteomics, 7(7), 1131-1139. PubMed

Sokolic L, McGregor IS (2007). Benzodiazepines impair the acquisition and reversal of olfactory go/no-go discriminations in rats. Behavioral Neuroscience 121: 527-534. PubMed

Thompson, M. R., Callaghan, P. D., Hunt, G. E., Cornish, J. L., & McGregor, I. S. (2007). A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine (“ecstasy”). Neuroscience, 146(2), 509-514. PubMed

Parrott, A. C., McGregor, I. S., Lee, T. M., Scholey, A. B., & Morgan, M. J. (2007). International Conference on Memory (ICOM-4), University of New South Wales, Sydney, Australia, 16-21 July 2006 Ecstasy/MDMA and Memory Symposium. J Psychopharmacol, 21(8), 895-897. PubMed

Chan-Ling, T., Hughes, S., Baxter, L., Rosinova, E., McGregor, I. S., Morcos, Y., Van Nieuwenhuyzen, P., & Hu, P. (2007). Inflammation and breakdown of the blood-retinal barrier during physiological aging in the rat retina: A model for CNS aging. Microcirculation. 14, 63-76. PubMed

Sokolic, L., Laing, D. G., & McGregor, I. S. (2007). Asymmetric suppression of components in binary aldehyde mixtures: behavioral studies in the laboratory rat. Chem Senses, 32(2), 191-199. PubMed

Clemens, K. J., McGregor, I. S., Hunt, G. E., & Cornish, J. L. (2007). MDMA, methamphetamine and their combination: possible lessons for party drug users from recent preclinical research. Drug Alcohol Rev, 26(1), 9-15. PubMed

Clemens, K. J., Cornish, J. L., Hunt, G. E., & McGregor, I. S. (2007). Repeated weekly exposure to MDMA, methamphetamine or their combination: long-term behavioural and neurochemical effects in rats. Drug Alcohol Depend, 86(2-3), 183-190. PubMed

 

2006

Clemens, K. J., Cornish, J. L., Hunt, G. E., & McGregor, I. S. (2006). Intravenous methamphetamine self-administration in rats: effects of intravenous or intraperitoneal MDMA co-administration. Pharmacol Biochem Behav, 85(2), 454-463.PubMed

Siviy, S. M., Harrison, K. A., & McGregor, I. S. (2006). Fear, risk assessment, and playfulness in the juvenile rat. Behav Neurosci, 120(1), 49-59. PubMed

Singh, M. E., McGregor, I. S., & Mallet, P. E. (2006). Perinatal exposure to delta(9)-tetrahydrocannabinol alters heroin-induced place conditioning and fos-immunoreactivity. Neuropsychopharmacology, 31(1), 58-69. PubMed

Iwazaki, T., McGregor, I. S., & Matsumoto, I. (2006). Protein expression profile in the striatum of acute methamphetamine-treated rats. Brain Res, 1097(1), 19-25. PubMed

O’Shea, M., McGregor, I. S., & Mallet, P. E. (2006). Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats. J Psychopharmacol, 20(5), 611-621. PubMed

Staples, L. G., & McGregor, I. S. (2006). Defensive responses of Wistar and Sprague-Dawley rats to cat odour and TMT. Behav Brain Res, 172(2), 351-354. PubMed

 

2005

McGregor, I. S., Dam, K. D., Mallet, P. E., & Gallate, J. E. (2005). Delta9-THC reinstates beer- and sucrose-seeking behaviour in abstinent rats: comparison with midazolam, food deprivation and predator odour. Alcohol Alcohol, 40(1), 35-45. PubMed

Hargreaves, G. A., McGregor, I. S., & Sachdev, P. S. (2005). Chronic repetitive transcranial magnetic stimulation is antidepressant but not anxiolytic in rat models of anxiety and depression. Psychiatry Res, 137(1-2), 113-121. PubMed

Singh, M. E., McGregor, I. S., & Mallet, P. E. (2005). Repeated exposure to Delta(9)-tetrahydrocannabinol alters heroin-induced locomotor sensitisation and Fos-immunoreactivity. Neuropharmacology, 49(8), 1189-1200. PubMed

Clemens, K. J., Cornish, J. L., Li, K. M., Hunt, G. E., & McGregor, I. S. (2005). MDMA (‘Ecstasy’) and methamphetamine combined: order of administration influences hyperthermic and long-term adverse effects in female rats. Neuropharmacology, 49(2), 195-207. PubMed

McGregor, I. S., Adamec, R., Canteras, N. S., Blanchard, R. J., & Blanchard, D. C. (2005). Defensive behavior. Neurosci Biobehav Rev, 29(8), 1121-1122. PubMed

Verty, A. N., McGregor, I. S., & Mallet, P. E. (2005). Paraventricular hypothalamic CB(1) cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)-tetrahydrocannabinol. Neuropharmacology, 49(8), 1101-1109.PubMed

Staples, L. G., Hunt, G. E., Cornish, J. L., & McGregor, I. S. (2005). Neural activation during cat odor-induced conditioned fear and ‘trial 2′ fear in rats. Neurosci Biobehav Rev, 29(8), 1265-1277. PubMed

R. Apfelbach, C.B. Blanchard, R.J. Blanchard, R. A. Hayes and I. S. McGregor (2005) Effects of predator odors on foraging, feeding and reproduction in mammalian prey species. Neuroscience and Biobehavioral Reviews, 29, 1123-1144.

Fendt, M., Endres, T., Lowry, C. A., Apfelbach, R., & McGregor, I. S. (2005). TMT-induced autonomic and behavioral changes and the neural basis of its processing. Neurosci Biobehav Rev, 29(8), 1145-1156. PubMed

Cornish, J. L., Lontos, J. M., Clemens, K. J., & McGregor, I. S. (2005). Cocaine and heroin (‘speedball’) self-administration: the involvement of nucleus accumbens dopamine and mu-opiate, but not delta-opiate receptors. Psychopharmacology (Berl), 180(1), 21-32. PubMed

Young, J. M., McGregor, I. S., & Mallet, P. E. (2005). Co-administration of THC and MDMA (‘ecstasy’) synergistically disrupts memory in rats. Neuropsychopharmacology, 30(8), 1475-1482. PubMed

Morley, K. C., Arnold, J. C., & McGregor, I. S. (2005). Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat. Prog Neuropsychopharmacol Biol Psychiatry, 29(5), 648-657. PubMed

 

2004

McGregor, I. S., Hargreaves, G. A., Apfelbach, R., & Hunt, G. E. (2004). Neural correlates of cat odor-induced anxiety in rats: region-specific effects of the benzodiazepine midazolam. J Neurosci, 24(17), 4134-4144. PubMed

Morley, K. C., Li, K. M., Hunt, G. E., Mallet, P. E., & McGregor, I. S. (2004). Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA (“Ecstasy”) in rats. Neuropharmacology, 46(7), 954-965.PubMed

Gallate, J. E., Mallet, P. E., & McGregor, I. S. (2004). Combined low dose treatment with opioid and cannabinoid receptor antagonists synergistically reduces the motivation to consume alcohol in rats. Psychopharmacology (Berl), 173(1-2), 210-216. PubMed

Morley, K. C., Cornish, J. L., Li, K. M., & McGregor, I. S. (2004). Preexposure to MDMA (“Ecstasy”) delays acquisition but facilitates MDMA-induced reinstatement of amphetamine self-administration behavior in rats. Pharmacol Biochem Behav, 79(2), 331-342. PubMed

Thompson, M. R., Li, K. M., Clemens, K. J., Gurtman, C. G., Hunt, G. E., Cornish, J. L., et al. (2004). Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA (‘Ecstasy’) in rats. Neuropsychopharmacology, 29(4), 694-704. PubMed

Ball, H. J., MacDougall, H. G., McGregor, I. S., & Hunt, N. H. (2004). Cyclooxygenase-2 in the pathogenesis of murine cerebral malaria. J Infect Dis, 189(4), 751-758. PubMed

Li, K. M., Thompson, M. R., & McGregor, I. S. (2004). Rapid quantitation of fluoxetine and norfluoxetine in serum by micro-disc solid-phase extraction with high-performance liquid chromatography-ultraviolet absorbance detection. J Chromatogr B Analyt Technol Biomed Life Sci, 804(2), 319-326. PubMed

Verty, A. N., McGregor, I. S., & Mallet, P. E. (2004). Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats. Neurosci Lett, 354(3), 217-220. PubMed

McGregor, I. S., & Gallate, J. E. (2004). Rats on the grog: novel pharmacotherapies for alcohol craving. Addict Behav, 29(7), 1341-1357. PubMed

Singh, M. E., Verty, A. N., McGregor, I. S., & Mallet, P. E. (2004). A cannabinoid receptor antagonist attenuates conditioned place preference but not behavioural sensitization to morphine. Brain Res, 1026(2), 244-253. PubMed

Verty, A. N., McFarlane, J. R., McGregor, I. S., & Mallet, P. E. (2004). Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake. Endocrinology, 145(7), 3224-3231. PubMed

Singh, M. E., Verty, A. N., Price, I., McGregor, I. S., & Mallet, P. E. (2004). Modulation of morphine-induced Fos-immunoreactivity by the cannabinoid receptor antagonist SR 141716. Neuropharmacology, 47(8), 1157-1169. PubMed

Verty, A. N., McGregor, I. S., & Mallet, P. E. (2004). The dopamine receptor antagonist SCH 23390 attenuates feeding induced by Delta9-tetrahydrocannabinol. Brain Res, 1020(1-2), 188-195. PubMed

Verty, A. N., McFarlane, J. R., McGregor, I. S., & Mallet, P. E. (2004). Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake. Neuropharmacology, 47(4), 593-603. PubMed

O’Shea, M., Singh, M. E., McGregor, I. S., & Mallet, P. E. (2004). Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats. J Psychopharmacol, 18(4), 502-508. PubMed

Clemens, K. J., Van Nieuwenhuyzen, P. S., Li, K. M., Cornish, J. L., Hunt, G. E., & McGregor, I. S. (2004). MDMA (“ecstasy”), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat. Psychopharmacology (Berl), 173(3-4), 318-325. PubMed

 

2003

Cornish, J. L., Shahnawaz, Z., Thompson, M. R., Wong, S., Morley, K. C., Hunt, G. E., et al. (2003). Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats. Eur J Pharmacol, 482(1-3), 339-341.PubMed

McGregor, I. S., Clemens, K. J., Van der Plasse, G., Li, K. M., Hunt, G. E., Chen, F., et al. (2003). Increased anxiety 3 months after brief exposure to MDMA (“Ecstasy”) in rats: association with altered 5-HT transporter and receptor density. Neuropsychopharmacology, 28(8), 1472-1484. PubMed

McGregor, I. S., Gurtman, C. G., Morley, K. C., Clemens, K. J., Blokland, A., Li, K. M., et al. (2003). Increased anxiety and “depressive” symptoms months after MDMA (“ecstasy”) in rats: drug-induced hyperthermia does not predict long-term outcomes. Psychopharmacology (Berl), 168(4), 465-474. PubMed

Norwood, C. S., Cornish, J. L., Mallet, P. E., & McGregor, I. S. (2003). Pre-exposure to the cannabinoid receptor agonist CP 55940 enhances morphine behavioral sensitization and alters morphine self-administration in Lewis rats. Eur J Pharmacol, 465(1-2), 105-114. PubMed

Verty, A. N., Singh, M. E., McGregor, I. S., & Mallet, P. E. (2003). The cannabinoid receptor antagonist SR 141716 attenuates overfeeding induced by systemic or intracranial morphine. Psychopharmacology (Berl), 168(3), 314-323.PubMed

Allen, K. V., McGregor, I. S., Hunt, G. E., Singh, M. E., & Mallet, P. E. (2003). Regional differences in naloxone modulation of Delta(9)-THC induced Fos expression in rat brain. Neuropharmacology, 44(2), 264-274. PubMed

Gallate, J. E., Morley, K. C., Ambermoon, P., & McGregor, I. S. (2003). The consequences of beer consumption in rats: acute anxiolytic and ataxic effects and withdrawal-induced anxiety. Psychopharmacology (Berl), 166(1), 51-60. PubMed

 

2002

Hunt, G. E., & McGregor, I. S. (2002). Contrasting effects of dopamine antagonists and frequency reduction on Fos expression induced by lateral hypothalamic stimulation. Behav Brain Res, 132(2), 187-201. PubMed

Gurtman, C. G., Morley, K. C., Li, K. M., Hunt, G. E., & McGregor, I. S. (2002). Increased anxiety in rats after 3,4-methylenedioxymethamphetamine: association with serotonin depletion. Eur J Pharmacol, 446(1-3), 89-96. PubMed

Green, A. R., & McGregor, I. S. (2002). On the anxiogenic and anxiolytic nature of long-term cerebral 5-HT depletion following MDMA. Psychopharmacology (Berl), 162(4), 448-450. PubMed

McGregor, I. S., Schrama, L., Ambermoon, P., & Dielenberg, R. A. (2002). Not all ‘predator odours’ are equal: cat odour but not 2,4,5 trimethylthiazoline (TMT; fox odour) elicits specific defensive behaviours in rats. Behav Brain Res, 129(1-2), 1-16. PubMed

 

2001

Dielenberg, R. A., & McGregor, I. S. (2001). Defensive behavior in rats towards predatory odors: a review. Neurosci Biobehav Rev, 25(7-8), 597-609. PubMed

Morley, K. C., Gallate, J. E., Hunt, G. E., Mallet, P. E., & McGregor, I. S. (2001). Increased anxiety and impaired memory in rats 3 months after administration of 3,4-methylenedioxymethamphetamine (“ecstasy”). Eur J Pharmacol, 433(1), 91-99. PubMed

Arnold, J. C., Hunt, G. E., & McGregor, I. S. (2001). Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats. Life Sci, 70(1), 97-108. PubMed

Arnold, J. C., Topple, A. N., Mallet, P. E., Hunt, G. E., & McGregor, I. S. (2001). The distribution of cannabinoid-induced Fos expression in rat brain: differences between the Lewis and Wistar strain. Brain Res, 921(1-2), 240-255. PubMed

Dielenberg, R. A., Hunt, G. E., & McGregor, I. S. (2001). “When a rat smells a cat”: the distribution of Fos immunoreactivity in rat brain following exposure to a predatory odor. Neuroscience, 104(4), 1085-1097. PubMed

Dielenberg, R. A., Carrive, P., & McGregor, I. S. (2001). The cardiovascular and behavioral response to cat odor in rats: unconditioned and conditioned effects. Brain Res, 897(1-2), 228-237. PubMed

 

2000

Morley, K. C., & McGregor, I. S. (2000). (+/-)-3,4-methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) increases social interaction in rats. Eur J Pharmacol, 408(1), 41-49. PubMed

Boot, B. P., McGregor, I. S., & Hall, W. (2000). MDMA (Ecstasy) neurotoxicity: assessing and communicating the risks. Lancet, 355(9217), 1818-1821. PubMed

Winters, B.D., Matheson, W., McGregor, I.S. & Brown, R.E. (2000) An automated two-choice test of olfactory working memory in the rat: effect of scopolamine. Psychobiology, 28, 21-31.

McGregor, I.S. and Schmidt, W.C. (2000). Models of the brain in psychology. In: E. Gordon (Ed). Integrative Neuroscience. Harwood Academic Publishers.

 

1999

Dielenberg, R. A., & McGregor, I. S. (1999). Habituation of the hiding response to cat odor in rats (Rattus norvegicus). J Comp Psychol, 113(4), 376-387. PubMed

McGregor, I. S., & Dielenberg, R. A. (1999). Differential anxiolytic efficacy of a benzodiazepine on first versus second exposure to a predatory odor in rats. Psychopharmacology (Berl), 147(2), 174-181. PubMed

Dastur, F. N., McGregor, I. S., & Brown, R. E. (1999). Dopaminergic modulation of rat pup ultrasonic vocalizations. Eur J Pharmacol, 382(2), 53-67. PubMed

Stephenson, C. P., Hunt, G. E., Topple, A. N., & McGregor, I. S. (1999). The distribution of 3,4-methylenedioxymethamphetamine “Ecstasy”-induced c-fos expression in rat brain. Neuroscience, 92(3), 1011-1023.PubMed

Vaughan, C. W., McGregor, I. S., & Christie, M. J. (1999). Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitro. Br J Pharmacol, 127(4), 935-940. PubMed

Gallate, J. E., Saharov, T., Mallet, P. E., & McGregor, I. S. (1999). Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist. Eur J Pharmacol, 370(3), 233-240. PubMed

Gallate, J. E., & McGregor, I. S. (1999). The motivation for beer in rats: effects of ritanserin, naloxone and SR 141716. Psychopharmacology (Berl), 142(3), 302-308. PubMed

Dielenberg, R. A., Arnold, J. C., & McGregor, I. S. (1999). Low-dose midazolam attenuates predatory odor avoidance in rats. Pharmacol Biochem Behav, 62(2), 197-201. PubMed

McGregor, I. S., Saharov, T., Hunt, G. E., & Topple, A. N. (1999). Beer consumption in rats: the influence of ethanol content, food deprivation, and cocaine. Alcohol, 17(1), 47-56. PubMed

 

1998

Topple, A. N., Hunt, G. E., & McGregor, I. S. (1998). Possible neural substrates of beer-craving in rats. Neurosci Lett, 252(2), 99-102. PubMed

McGregor, I. S., Arnold, J. C., Weber, M. F., Topple, A. N., & Hunt, G. E. (1998). A comparison of delta 9-THC and anandamide induced c-fos expression in the rat forebrain. Brain Res, 802(1-2), 19-26. PubMed

Arnold, J. C., Topple, A. N., Hunt, G. E., & McGregor, I. S. (1998). Effects of pre-exposure and co-administration of the cannabinoid receptor agonist CP 55,940 on behavioral sensitization to cocaine. Eur J Pharmacol, 354(1), 9-16. PubMed

Hunt, G. E., & McGregor, I. S. (1998). Rewarding brain stimulation induces only sparse Fos-like immunoreactivity in dopaminergic neurons. Neuroscience, 83(2), 501-515. PubMed

McGregor, I. S., & Lee, A. M. (1998). Changes in respiratory quotient elicited in rats by a conditioned stimulus predicting food. Physiol Behav, 63(2), 227-232. PubMed

 

1997

Jinks, A. L., & McGregor, I. S. (1997). Modulation of anxiety-related behaviours following lesions of the prelimbic or infralimbic cortex in the rat. Brain Res, 772(1-2), 181-190. PubMed

McGregor, I. S. (1997). Marijuana addiction. Science, 277(5327), 749-750; author reply 750-742. PubMed

Lin, H. Q., Jackson, D. M., Atrens, D. M., Christie, M. J., & McGregor, I. S. (1997). Serotonergic modulation of 3,4-methylenedioxymethamphetamine (MDMA)-elicited reduction of response rate but not rewarding threshold in accumbal self-stimulation. Brain Res, 744(2), 351-357. PubMed

 

1996

McGregor, I. S., Dastur, F. N., McLellan, R. A., & Brown, R. E. (1996). Cannabinoid modulation of rat pup ultrasonic vocalizations. Eur J Pharmacol, 313(1-2), 43-49. PubMed

McGregor, I. S., Issakidis, C. N., & Prior, G. (1996). Aversive effects of the synthetic cannabinoid CP 55,940 in rats. Pharmacol Biochem Behav, 53(3), 657-664. PubMed

I.S. McGregor (1996). Using Strawberry Tree WorkBench Mac and Workbench PC for data acquisition and control in the animal learning laboratory. Behavior Research Methods, Instruments and Computers, 28, 38-48.

 

1995

McGregor, I. S., & Lee, A. M. (1995). Metabolic changes associated with ingestion of different macronutrients and different meal sizes in rats. Physiol Behav, 57(2), 277-286. PubMed